Fig. 4

PML-RARα interrupted the transcription activity of key transcription factors. a Motif enrichments of hematopoietic transcription factor at PML-RARα binding sites. b Venn diagrams of the overlapped binding sites by three TFs (PU.1, CEBPB, and IRF1) in PR9 and PR9+Zn cells. c Two examples (left, on chr11; right, chr20) showing PML-RARα binding and looping, where the occupancy by H3K9K14ac (pink), P300 (red), PU.1 (orange), CEBPB (green), and IRF1 (blue) in PR9 cells was notably reduced in PR9+Zn cells. The promoter site is highlighted in light red, and the enhancer sites are highlighted in light blue