Fig. 2

Overview of tappAS modules for Functional Iso-Transcriptomics analysis. Module I contains a novel qualitative approach to evaluate the functional diversity of alternative isoforms. Module II implements differential expression and differential isoform usage analyses to compare AltTEM and gene expression. Module 3 includes newly developed approaches to measure the functional impact of AltTEM as changes in the inclusion of functional features, polyA site usage, and UTR length