TY - JOUR AU - Rubel, Meagan A. AU - Abbas, Arwa AU - Taylor, Louis J. AU - Connell, Andrew AU - Tanes, Ceylan AU - Bittinger, Kyle AU - Ndze, Valantine N. AU - Fonsah, Julius Y. AU - Ngwang, Eric AU - Essiane, André AU - Fokunang, Charles AU - Njamnshi, Alfred K. AU - Bushman, Frederic D. AU - Tishkoff, Sarah A. PY - 2020 DA - 2020/05/25 TI - Lifestyle and the presence of helminths is associated with gut microbiome composition in Cameroonians JO - Genome Biology SP - 122 VL - 21 IS - 1 AB - African populations provide a unique opportunity to interrogate host-microbe co-evolution and its impact on adaptive phenotypes due to their genomic, phenotypic, and cultural diversity. We integrate gut microbiome 16S rRNA amplicon and shotgun metagenomic sequence data with quantification of pathogen burden and measures of immune parameters for 575 ethnically diverse Africans from Cameroon. Subjects followed pastoralist, agropastoralist, and hunter-gatherer lifestyles and were compared to an urban US population from Philadelphia. SN - 1474-760X UR - https://doi.org/10.1186/s13059-020-02020-4 DO - 10.1186/s13059-020-02020-4 ID - Rubel2020 ER -