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Fig. 4 | Genome Biology

Fig. 4

From: A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk

Fig. 4

a TPSAB1 (encoding Tryptase α/β 1) is highly expressed in immune cells in both adenocarcinoma and SCC. b, c TPSAB1 expression in immune cells was negatively associated with proliferation and metastasis-related genes in adenocarcinoma (b), while in SCC there was a negative association with invasiveness and angiogenesis but a positive association with proliferation. d Representative stains for cellular proliferation marker KI67, and MCT in samples that had high (top) and low (bottom) expression of TPSAB1. Shown are × 20 magnification image; see Supplementary Figures 8 and 9 for × 40 and × 60. e Primary adenocarcinomas with higher numbers of infiltrating mast cells had a lower proportion of KI67-positive (proliferating) malignant cells (p = 0.003; F-test). f, g High numbers of mast cells in both primary adenocarcinomas (f) and SCC (g), assessed by tissue microarray staining for mast cell tryptase (MCT), were associated with better overall survival. Mast cell counts were assigned to pre-defined “none,” “low,” “medium,” and “high” categories by pathologist

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