Fig. 5

CircRNA annotation based on an integrated network of circRNAs, mRNAs, miRNAs, and RBPs. a Workflow of network construction. Briefly, the co-expression network was initially built based on the expression correlation between circRNAs and mRNAs. Then, circRNA-miRNA and circRNA-RBP interactions were added to the existing co-expression network. Finally, the potential GO and the KEGG functions of the circRNAs were predicted using the connected mRNAs, miRNAs, and RBPs. b Comparison of circAtlas with other circRNA annotation databases. c The top 10 most frequently interacting RBPs and miRNAs in the network. d The top 10 annotated KEGG pathways of the circRNAs. e Validation of accuracy of the circAtlas annotation using reported circRNAs. The x- and y-axes indicate the types of diseases and the number of circRNAs that have been reported (green) to be associated with diseases or have novel annotations (gray), respectively