Table 1 List of significantly dysregulated RMPs identified using dysregulation score-based analysis
From: Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
Short name | Cancer type | Upregulated RMPs | Downregulated RMPs |
|---|---|---|---|
ACC | Adrenocortical carcinoma | BUD23, FBL, LAGE3, TRMT112, VIRMA | ADAT2, APOBEC3G, TARBP1 |
BLCA | Bladder urothelial carcinoma | HENMT1 | ADARB1 |
BRCA | Breast invasive carcinoma | LAGE3 | TRMT9B |
CESC | Cervical squamous cell carcinoma and endocervical adenocarcinoma | APOBEC3A, HENMT1 | – |
COAD | Colon adenocarcinoma | APOBEC1, DKC1, HENMT1 | ADARB1 |
ESCA | Esophageal carcinoma | HENMT1, RBM15, ZC3H13 | ADAD2, METTL17 |
GBM | Glioblastoma multiforme | APOBEC3G, HSD17B10 | ADARB2, FBLL1, TARBP1 |
HNSC | Head and neck squamous cell carcinoma | HENMT1 | – |
KICH | Kidney chromophobe | ISCU | – |
KIRC | Kidney renal clear cell carcinoma | APOBEC3G | – |
KIRP | Kidney renal papillary cell carcinoma | METTL27 | – |
LAML | Acute myeloid leukemia | APOBEC3A, HENMT1 | – |
LGG | Brain lower-grade glioma | HSD17B10, TRMT5 | ADARB1, HENMT1, TARBP1 |
LIHC | Liver hepatocellular carcinoma | LAGE3, METTL27, TARBP1 | ADAT2, METTL17, NSUN6, TRMT11, ZC3H13 |
LUAD | Lung adenocarcinoma | LAGE3, METTL1, TFB2M | ADARB1, APOBEC3A,TRMT9B |
LUSC | Lung squamous cell carcinoma | DKC1, FBL, LAGE3, METTL1, METTL8 | ADARB1, TRMT9B |
OV | Ovarian serous cystadenocarcinoma | – | YTHDC2 |
PAAD | Pancreatic adenocarcinoma | APOBEC1, APOBEC3G, HENMT1 | QTRT1, WDR6 |
PCPG | Pheochromocytoma and paraganglioma | FBLL1 | MPST |
PRAD | Prostate adenocarcinoma | – | APOBEC3G, METTL17 |
READ | Rectum adenocarcinoma | APOBEC1, DKC1, HENMT1 | ADARB1 |
SARC | Sarcoma | HENMT1 | ADARB1, ISCU, SERGEF |
SKCM | Skin cutaneous melanoma | APOBEC3G | – |
STAD | Stomach adenocarcinoma | HENMT1 | METTL17,TRMT2A, WDR6 |
TGCT | Testicular germ cell tumors | EMG1, FBL, HNRNPC, HSD17B10, LAGE3, METTL9 | ADAD1, ADAD2 |
THCA | Thyroid carcinoma | LAGE3, TRMT112 | ADAT2, METTL17, TRMT9B, TRMU |
UCEC | Uterine corpus endometrial carcinoma | LAGE3 | ADARB1 |
UCS | Uterine carcinosarcoma | FBL, HENMT1, HSD17B10, LAGE3, TRMT112 | Â |