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Fig. 6 | Genome Biology

Fig. 6

From: Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Fig. 6

Artemether effects on beta cells are species dependent. a Spearman correlations of log fold changes of comparisons of 1 μM FoxOi, 10 μM artemether, or 100 μM GABA to DMSO for alpha and beta cells from mouse and human islets. b FoxOi induces dedifferentiation of alpha and beta cells in mouse and human, while artemether increases the fraction of INS+ alpha cells. In beta cells, artemether effects are species dependent; in mouse, the drug induces beta cell dedifferentiation, while in human there are no strong effects

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