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Fig. 5 | Genome Biology

Fig. 5

From: Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Fig. 5

Artemether upregulates insulin in a subset of mouse and human alpha cells while effects in beta cells are species dependent. a Inverse cumulative distribution of insulin expression in assigned alpha cells from human (INS) and mouse (Ins1 and Ins2) islets treated with 1 μM FoxOi or 10 μM artemether or DMSO for 72 h. Plotted is the fraction of alpha cells that express insulin to a higher level as indicated on the x-axis. b Correlation of gene expression signatures in alpha cells without (Ins−) and with (Ins+) detectable insulin expression alpha or beta cell gene signature sets. c Gene expression changes of Ins+ alpha cells relative to Ins− alpha cells. d Inverse cumulative distribution of insulin expression in beta cells from human (INS) and mouse (Ins1 and Ins2) islets treated with 1 μM FoxOi or 10 μM artemether or DMSO for 72 h. e Gene expression changes in human and mouse beta cells treated with 10 μM artemether or 1 μM FoxOi compared to DMSO

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Genome Biology

ISSN: 1474-760X

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