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Fig. 4 | Genome Biology

Fig. 4

From: Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Fig. 4

FoxOi induces dedifferentiation in alpha and beta cells of human and mouse islets. a Insulin expression in beta cells from human (INS) and mouse (Ins1 and Ins2) islets treated with 1 μM FoxOi for 72 h (*p < 10−10, **p < 10−45). b GSEA with the set of upregulated genes in triple Foxo knockout mice (FoxO1−/−, FoxO3a−/−, and FoxO4−/−) [57] in beta cells from human and mouse islets treated with 1 μM FoxOi for 72 h. c Gene expression changes in alpha (top) and beta (bottom) cells from human and mouse islets treated with 1 μM FoxOi for 72 h compared to DMSO treatment. d Correlation of alpha and beta cell gene expression from human and mouse islets treated with 1 μM FoxOi for 72 h to an alpha or beta cell gene signature set

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Genome Biology

ISSN: 1474-760X

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