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Fig. 2 | Genome Biology

Fig. 2

From: Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Fig. 2

Accurate computational correction of cellular signatures based on spike-in cells. a Mouse spike-ins are used to estimate the fraction of contamination fc and the signature of contamination Sc. b Predicted versus measured fc. c, d Pearson correlation of raw (black) and corrected (red) values of the spike-ins in the human and mouse samples to the external reference spike-in transcriptome. e Flow diagram of data correction of DMSO samples from donors I and II. Left to right: 1—Scatter plot of raw INS and GCG from human donors I and II. 2 and 3—Density plots of donors separately of raw and corrected data. 4—Scatter plot of corrected INS and GCG from human donors I and II. ***p < 0.0001, **p < 0.001, *p < 0.005

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Genome Biology

ISSN: 1474-760X

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