Fig. 3
From: Lamina-associated domains: peripheral matters and internal affairs
Heterogeneous spatial distribution of LADs in individual cells. a Schematic representation of five LADs in a fictive ensemble ChIP-seq experiment (browser view) and in four fictive 3D genome models recapitulating the heterogeneity of LAD positioning in individual cells in a population [14]. b FISH image of five labeled LADs (within circles) in both homologous chromosomes 4 in human primary adipose stem cells. Note the variation between cells in the position of these LADs relative to each other and to the nuclear edge, and the heterogeneity of relative LAD positions between two homologous chromosomes (our unpublished data). cm6A tracer visualization of LAD reassembly post-mitosis in daughter nuclei. LAD targeting to the nuclear periphery occurs during G1 phase [15]. Reproduced from [15] with permission