Fig. 3
From: Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
Micro-CT assessment of the distal femur from 15-week-old male Ripk3−/− and WT mice. Representative 3D images of the distal femur demonstrate the following: a reduced extension of the trabecular network into the diaphysis, b expansion of the medullary cavity and c increased size of the trabecular bone compartment with no change in trabecular bone density in the Ripk3-/- mice. Quantitative analysis of micro-CT parameters (mean + standard deviation) displays the following: d cortical volume, e bone marrow volume, f endosteal perimeter, g periosteal perimeter, h trabecular bone volume fraction and i trabecular extension in the Ripk3−/− mice relative to WT mice. N = 5 for each group; WT, wildtype. **P < 0.01