Fig. 4From: TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcriptionTAD splits and mergers are associated with changes in gene expression. a Boxplot indicating the expression level of genes at the two sides of TAD split sites before and after splitting. b Arc plot showing the chromatin interactions (top) and gene expression (bottom) at 5 stages of T cell lineage specification. One gene from each side of the split site was indicated. c Heatmaps of split scores for individual split sites (top panels) and fold difference of gene expression between the two sides of the split site (bottom panels) at 8 stages of T cell lineage specification. Genes with an expression value (FPKM) larger than 1 were analyzedBack to article page