Fig. 7
From: Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome
Craniofacial abnormality, relative macrocephaly, and body asymmetry observed in SRS model mice. a Craniofacial feature was examined by 3D image reconstructed from CT scan of a mouse. Linear measurements obtained from each pair of landmarks (nasal bone, edge of occipital bone, glabella, and lateral angle of eye) were shown by arrows. The ratio of two parameters (x/y) was compared between vector integrated and not integrated mice. * P < 0.05, ** P < 0.01 (two-tailed Student’s t test). b Organ weight per body weight (w/w) of vector integrated and not integrated mice. Increase of relative brain weight (w/w) associated with macrocephaly was observed in vector-integrated mice (arrows). c 3D images of a mouse with relative macrocephary (TG4) and a control mouse (WT1) are shown. d 3D image reconstructed from CT scan of a mouse which showed body asymmetry in the humerus bone (TG5) and a control mouse (WT1). The ratio of right and left limb bone lengths was calculated from 3D image of a mouse. The bar graphs show the ratio of the long length to the short length. Body asymmetry was observed in the humerus bone of epigenome-edited mice (TG5, arrow)