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Fig. 2 | Genome Biology

Fig. 2

From: HiNT: a computational method for detecting copy number variations and translocations from Hi-C data

Fig. 2

Copy number inference in K562 cells. a Comparison of log2 copy ratios calculated using regression residuals from Hi-C (blue) and using read coverage from WGS (orange). b Comparison of CNV profiles from Hi-C, array CGH, and WGS after segmentation. Red, green, and gray bars represent copy gain (log2 copy ratio > 0.3), copy loss (log2 copy ratio < − 0.3), and copy neutral regions (log2 copy ratio between − 0.3 and 0.3), respectively. c The number of CNV segments (categorized by size) detected from Hi-C that are also supported by WGS. Specifically, 85.91%, 44.74%, and 60.98% of the large CNV segments identified by HiNT, HiCnv, and OneD are supported by those from WGS, respectively. The overlap criteria for consistency are shown in Additional file 1: Fig. S5C

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