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Fig. 3 | Genome Biology

Fig. 3

From: Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

Fig. 3

The topology of spatial chromatin contacts of super-enhancer with the Pcdh β and γ promoters. a QHR-4C interaction profiles with the CBS f of the downstream super-enhancer as a viewpoint in cortical tissues of mice with a series of deletions of individual CTCF sites or their combinations. b QHR-4C interaction profiles with the CBS f of the downstream super-enhancer as a viewpoint using cells transfected with dCas9 only or dCas9 with sgRNAs targeting individual CTCF sites or their combinations to pinpoint the effects to CTCF sites. c, d QHR-4C interaction profiles with the upstream Pcdhβ17 promoter CBS as a viewpoint in mice with CTCF site deletions or in cells with dCas9-blocked CTCF sites confirm the decreased interactions with the downstream super-enhancer. WT, wild-type; del, deletion

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