Fig. 7

Mixture models. a, b Distributions of detected isoforms per gene per cell (blue) and log normal fitted distributions (orange) for H1 cells sequenced at 1 million reads per cell (a) or 4 million reads per cell (b) under the Weibull model. c, d Mixing fractions vs iterations of expectation maximisation for 1 million reads per cell (c) and 4 million reads per cell (d). Each coloured line represents the distributions for one, two, three or four isoforms being simulated as expressed per gene per cell. Equivalent plots for other isoform choice models and H9 cells can be found in Additional file 1: Figs. S25–31