Table 1 Features used by RADAR
Category | Feature | Source | Scoring scheme |
|---|---|---|---|
Universal | Cross-population conservation | eCLIP | Adjusted entropy |
Cross-species conservation | GERP | Sigmoid function | |
Structural conservation | Evofold | Fixed value | |
RBP Binding hub | eCLIP | Adjusted entropy | |
RBP-gene association | shRNA RNA-Seq | Fixed value | |
Motif disruption | Bind-n-Seq | Adjusted entropy | |
DREME | |||
User-specific | RBP regulatory potential | Expression | Fixed value |
Differentially expressed genes | Prior knowledge | Fixed value | |
Mutation recurrence | Mutation profiles | Fixed value |