Fig. 3

Cross-population conservation of RBP peaks and binding hubs. a, b Rare variant percentage in coding/noncoding regions. The green dot represents RBP peaks, and the yellow dot represents the genome average after GC correction. Shaded lines are the 95% confidence interval of the rare variant percentage of the RBP peaks. c An example of RBP binding hubs. Red and orange shadings denote regions with the top 1% (ultra-hot) and 5% (hot) RBPs binding, respectively. d Corrected rare variant percentage at positions with different cumulative hub numbers