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Fig. 7 | Genome Biology

Fig. 7

From: Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Fig. 7

Microbiome and Smarcad1-dependent colitis susceptibility. a Alpha-diversity plots before and after microbiome enrichment, as well as donor microbiota, shown as observed species number (left) and chao-quantitation (right). Outliers (*) were identified with the ROUT algorithm in GraphPad Prism with the Q-cutoff set to 0.1%. Outliers were omitted for the following statistical analysis by 1-way ANOVA with Holm-Sidak’s multiple comparison test, p values indicated. SEM indicated by error bars. Full statistical results are listed in Additional file 2: Table S1. b Beta-diversity plot based on unweighted unifrac diversity distance (phylogenetic distance analysis of detected OTUs). Outliers previously detected based on alpha-diversity are indicated in gray. c Heat map of log10 transformed OTU abundance at the phylum level identifies TM7 as a phylum transferred on microbiota enrichment; see Additional file 1: Fig. S8 for other phylogenetic levels. Phylogenetic terms significantly different between initial and enriched microbiota (FDR < 0.1, Wilcoxon test, n = 20, outliers not excluded) are indicated with FDR and fold changes (enriched/initial). Terms shown in d are underlined. d Taxa substantially changed on microbiota enrichment (> 2-fold change, Wilcoxon test FDR < 0.05, n = 20, outliers not excluded) are indicated with FDR and fold changes between enriched and initial microbiota groups. Disease associations shown represent one or more previous studies in feces/colon biopsies from humans or mouse [49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64]. Where the cited studies have shown contradicting interactions, the predominant interactions are indicated

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