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Table 1 Algorithms for analyzing CRISPR-pooled screen data

From: A benchmark of algorithms for the analysis of pooled CRISPR screens

AlgorithmOriginal purposeFDRs?Guide inefficiencies?Negative controls?Single or multiple screens?
RSARNAiNoNoNoSingle
MAGeCK RRACRISPRkoYesNoYesSingle
HiTSelectCRISPRko & RNAiYesYesYesSingle
MAGeCK MLECRISPRkoYesYesYesBoth
BAGELCRISPRko essentialityYesNoYesSingle
CERESCRISPRko in cancerYesYesNoMultiple
CRISPhieRmixCRISPRi/aYesYesYesSingle