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Table 1 Algorithms for analyzing CRISPR-pooled screen data

From: A benchmark of algorithms for the analysis of pooled CRISPR screens

Algorithm Original purpose FDRs? Guide inefficiencies? Negative controls? Single or multiple screens?
RSA RNAi No No No Single
MAGeCK RRA CRISPRko Yes No Yes Single
HiTSelect CRISPRko & RNAi Yes Yes Yes Single
MAGeCK MLE CRISPRko Yes Yes Yes Both
BAGEL CRISPRko essentiality Yes No Yes Single
CERES CRISPRko in cancer Yes Yes No Multiple
CRISPhieRmix CRISPRi/a Yes Yes Yes Single