Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: Accurate targeted long-read DNA methylation and hydroxymethylation sequencing with TAPS

Fig. 2

lrTAPS of a previously unmapped region in mESCs and integrated HBV DNA in Huh-1 cells. a Genome browser view of the methylation and coverage detected by Illumina-TAPS, Nano-TAPS, and SMRT-TAPS in Hba-a1 locus. The pink shaded area shows the gap which cannot be mapped with Illumina short-read sequencing. b CpG methylation of integrated HBV DNA in Huh-1 cells detected by Nano-TAPS and SMRT-TAPS. The blue shaded area shows the covered regions with lrTAPS. Regions of methylated CpGs are indicated by the blue/yellow boxes. c Heatmap showing integrated HBV DNA methylation in each SMRT read (34,755 reads were included). Reads were ranked by the average methylation in the first CpG Island. The blue bar indicates the methylated CpG (mCG) while white bar indicates unmethylated CpG (uCG). The number in the bottom indicates the relative position of CpG in the HBV reference genome

Back to article page