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Fig. 5 | Genome Biology

Fig. 5

From: Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

Fig. 5

Effects of NR4A1, BATF, and VDR expression and methylation status of their PDCD1 binding sites on PDCD1 expression. a Scatter plots and trend lines were plotted to illustrate the correlation between PDCD1 expression and three TF (NR4A1, BATF, and VDR) expressions. Colors of dots represent the methylation levels of the promoter regions of PDCD1. Each dot represents a replicate of one patient. R, regression coefficient; adj. P, Benjamini-Hochberg adjusted p value. b In silico FACS analysis of our previous scRNA-seq data of CD8+ T cells from CRC patients. The percentages of double-positive cells for PDCD1 and TF in the corresponding TF-positive cells are calculated in three TIL subtypes, respectively

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Genome Biology

ISSN: 1474-760X

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