Fig. 4

Key transcription factors and their targets for each CD8+ T cell subtype. a Selected TF motifs enriched in HypoMRs for five subtypes. Q value here represents adjusted p value reported by HOMER. b Target (y-axis) vs. background (x-axis) sequences with motif in CD103+CD39+ subtypes. c RNA expression of BATF, NR4A1, VDR, and EGR2 in five subtypes. d–f Computed gene regulatory networks showing transcription factor BATF (d), NR4A1 (e), and VDR (f) and their target genes. TFs and their targets of interest are labeled in red