Fig. 3

Somatic mutational strand asymmetries. a Mutation average and S.D. for each strand with respect to transcription (left and middle panels) and the ratio of mean mutations on the transcribed over the non-transcribed strand (right panel). b Distribution of z-scores for mutation averages and standard deviations on each strand (from panel a) across all samples. c Example of intra-individual correlation of C>A strand asymmetry in two tissues; each point represents an individual for which we generated mutation maps in the two tissues (see Additional file 1: Figure S7a for all tissue pairwise comparisons). d Correlation of mutational strand biases between calls from RNA-seq and matched DNA-seq; each point represents the mutation strand bias observed in one gene across all 105 blood samples. Blue lines in all scatter plots are based on a linear regression; rho values are the Spearman correlation coefficients