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Fig. 6 | Genome Biology

Fig. 6

From: PASTMUS: mapping functional elements at single amino acid resolution in human cells

Fig. 6

Functional maps of PSMB5, PLK1, and HPRT1 at structure level. a Surface diagram of PSMB5 with Bortezomib. PSMB5 is shown in gray, and critical sites enriched in PASTMUS are shown in cyan. Bortezomib is shown in yellow (PDB code: 5LF3). b Zoomed-in view shown the interface of PSMB5 and Bortezomib. c Structural comparison of PSMB5 M104, M104I, and M104V interacts with Bortezomib (PDB code: 2F16, 4QVN, and 4QVQ). d Surface diagram of PLK1 with BI2536. PLK1 is shown in gray, and critical sites are shown in cyan. BI2536 is shown in yellow (PDB code: 2RKU). e Zoomed-in view shown the interface of PLK1 and BI2536. f Interaction of PLK1 F183 and BI2536. g Surface diagram of HPRT1 with bound GMP. HPRT1 is shown in gray, and critical sites are shown in blue (critical sites known for dimer or tetramer interaction are colored dark blue) (PDB code: 1HMP). h Zoomed-in view shown the interface of HPRT1 and GMP

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