Fig. 5From: PASTMUS: mapping functional elements at single amino acid resolution in human cellsSubstitution pattern analysis of top hits from PSMB5 and PLK1. a Heat maps showing the substitution pattern of top amino acids of PSMB5 and PLK1. The 20 amino acids are classified into 4 groups with different colors according to their side-chain properties: non-polar (purple), polar (aqua), acidic (yellow), and basic (red). b PSMB5 M104 substitution pattern enriched in PASTMUS. c The expression of all PSMB5 M104 substitution variants. d Effects of M104 substitution variants on Bortezomib-mediated cell cytotoxicity with indicated dosages. Data are presented as the mean ± SD, n = 3Back to article page