Fig. 1From: PASTMUS: mapping functional elements at single amino acid resolution in human cellsRationale for acquiring residues critical for protein function based on phenotypic changes associated with in-frame mutations. a Category of genotypes or proteins due to CRISPR mutagenesis. b Genotypes conferring loss-of-function phenotype (for recessive mutant) and genotypes conferring gain-of-function phenotype (dominant mutant)Back to article page