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Fig. 7 | Genome Biology

Fig. 7

From: Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type

Fig. 7

Genomic instability and weakening of DNA repair with aging. a Number of clones showing large chromosomal aberrations per tissue and age group. Young 21–38, old 63–78. b Fraction of genomes showing large chromosomal aberrations in the samples analyzed in a, but divided in tighter age groups (10 year-span). c Enrichment/depletion of mutations according to DNA replication timing (RT) while controlling for CTCF binding sites in either younger (< 50 years old, N = 52) or older (> 50 years, N = 54) genomes from the tissues not showing signs of exposure to external mutagens (SkM, SAT, VAT, intestine, and colon, according to the analyses in Figs. 3 and 6). Enrichments are coefficients from negative binomial regression (as log2), and error bars are their 95% C.I. Significance of young-vs-old differences was tested via a Z-test on the interaction term between age and replication time bin d. Fraction of SBS5 mutations per genome in different age groups of SkM, SAT, VAT, blood, intestine, and colon cells. *P < 0.05, one-way ANOVA and multiple comparison tests

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