Fig. 4

The abundance of Enterococcus in the fecal microbiota is associated with inflammation in the colon. The fecal transplantation experiment data shown in Figs. 2 and 3 were reanalyzed taking into consideration data generated from 16S rRNA-based metagenomic analysis of the mouse gut microbiota. a LDA was performed using LEfSe to determine significant differences in the relative abundance of specific genera in the feces of mice transplanted with HD and UC microbiota (top), or HD and CD microbiota (bottom). Differentially abundant genera for which the LDA scores indicated a P value < 0.05 are shown in the graphs. b Spearman’s rank correlation between pathology score or mRNA expression of certain cytokines in the colon tissues of the mice and the relative abundance or copy number of Enterococcus in the feces was visualized. Copy number of E. faecium or E. faecalis per gram of feces was determined by quantitative PCR. *P < 0.05; **P < 0.01; ***P < 0.001