Fig. 2
From: Chromatin interactome mapping at 139 independent breast cancer risk signals
Promoter-interacting regions (PIRs) are enriched for regulatory features. Heatmaps showing PIR enrichment for a ATAC-seq peaks in breast cell lines, b histone marks by ChIP-seq in available breast cell lines, and c transcription factor binding in available breast cell lines, expressed as z-scores. The red outlines highlight key enrichment signals. d The number of interactions between expression single nucleotide polymorphisms (eSNPs) and associated target genes (observed) compared to randomly assigned interactions (random), binned by interaction distance. Asterisks represent the significance of enrichment of observed versus randomized interacting regions (permutation test *p < 0.05, **p < 0.01, ***p < 0.001)