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Fig. 4 | Genome Biology

Fig. 4

From: The majority of A-to-I RNA editing is not required for mammalian homeostasis

Fig. 4

Adar1E861A/E861AAdarb1−/− have lost A-to-I editing across the transcriptome. a Analysis of A-to-I editing of the Htr2c receptor at the known sites A–D by Sanger sequencing. Genotypes as indicated. b Analysis of editing sites across the genotypes. A dataset of 57,077 murine editing sites was compiled and the datasets assessed for editing at these sites. Sites required ≥ 50 read coverage and an editing rate of ≥ 0.01 (≥ 1%) to be included. The number that passed this threshold for each comparison is listed, and the numbers that are significantly different based on the z factor (z ≥ 5; Jacusa analysis method) are indicated in red. c Editing frequency across coding/site-selective and repetitive/hyperediting sites in the transcriptome in the individual samples from the WT, dHet, Adar1E861A/E861A, and Adarb1−/−. Sites required ≥ 50 read coverage and an editing rate of ≥ 0.01 (≥ 1%) to be considered. Boxplot represents the 25% quantile to 75% quantile with the median indicated. d Editing of the 3′UTR of Rpa1 transcript in each of the indicated genotypes

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