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Fig. 1 | Genome Biology

Fig. 1

From: The majority of A-to-I RNA editing is not required for mammalian homeostasis

Fig. 1

A-to-I editing-deficient mice are viable with a normal lifespan. a Breeding data from intercrosses of Adar1E861A/+Ifih1−/−Adarb1−/−Gria2R/R males and females. b Breeding data from intercrosses of Adar1E861A/E861AIfih1−/−Adarb1−/−Gria2R/R males with Adar1E861A/+Ifih1−/−Adarb1−/−Gria2R/R females. c Survival data for all genotypes; numbers per genotype and statistical comparison across all genotypes (pairwise log-rank (Mantel-Cox) test); P value as indicated or ***P < 0.001. d Comparison of survival of Adarb1−/−Gria2R/+ animals with either heterozygous Adar1E861A/+ (purple and pink lines) or homozygous Adar1E861A/E861A (yellow) and calculated median survival in days. e Comparison of survival of Adar1E861A/+Ifih1−/−Adarb1+/−Gria2R/R (double heterozygous) and Adar1E861A/E861AIfih1−/−Adarb1−/−Gria2R/R. f Weaning weight (~ 20 days of age) of the indicated genotypes; both males and females included. *P < 0.05, **P < 0.01, ***P < 0.001 (ordinary one-way ANOVA with multiple comparisons correction (Tukey’s)). g Body weight and body mass composition of 12-week-old males of the indicated genotypes; n per genotype: C57Bl/6 = 8 (white circle); dHet (Adar1E861A/+Ifih1−/−Adarb1+/−Gria2R/R) = 5 (gray); Adar1E861A/E861AAdarb1+/+ (Ifih1−/−Gria2+/+) = 3 (red); Adar1+/+Adarb1−/− (Ifih1−/−Gria2R/R) = 3 (green); Adar1E861A/E861AAdarb1−/− (Ifih1−/−Gria2R/R) = 3 (blue); *P < 0.05 (ordinary one-way ANOVA with multiple comparisons correction (Tukey’s))

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