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Table 1 Chromatin modifiers, binding factors and functions of selected PTMs on histones

From: Epigenetic modifications of histones in cancer

HistonesModificationModifiersBinding factorsFunctionsReference
H2AK119Ub1RING1A/BBAP1, USP16, USP21, 2A-DUB, USP3, USP22 Transcriptional repression[12, 13]
H2AXS139p (γH2AX)ATM, ATR, DNA-PKPP2A, Wip1, PP6 and PP4MDC1, CRB2DNA repair[14]
H2BK120Ub1RNF20, RNF40USP3, USP7, USP22 Transcriptional activation, DNA damage response[15]
H3K4me1/2/3SET1A/B, MLL1-4KDM1A/B, KDM2A/B, KDM5A/B/C/DBRWD2/PHIP, MLL,TAF3, CHD1,RAG2, BPTF, PHF2/6/8, JMJD2Transcriptional activation[16,17,18]
K9me1/2/3Suv39H1/2, G9a, GLP, SETDB1KDM1A, KDM3A/B, JMJD1C, KMD4A/B/C/DHP1, ATRXTranscriptional activation (K9me1), repression (K9me2/3), X-inactivation and imprinting (K9me2)[19]
S10pAurora B, MSK/RSK/Jil-1PP2A, PP114–3-3ζMitosis, meiosis, transcriptional activation[20]
R26me2CARM1PADI4 Transcriptional activation[21]
K27 acCBP/p300HDACsBRDsTranscriptional activation[22]
K27me1/2/3EZH1/2KDM6A/B, KDM7A, PHF8EED, PC, CBX7Transcriptional activation (K27me1); Transcriptional silencing, X-inactivation, bivalent genes/gene poising (K27me2/3)[23]
K36me1/2/3NSD1–3, SETD2/3, ASH1L, SETMAR, SMYD2KDM2A/B, KDM4A/B/C/D, JHDM1AZYMND11, PHF19, LEDGFTranscriptional elongation, repression, DNA repair[19]
K79me1/2/3DOT1L?p53BP1Transcriptional activation[24]
H4K20me1PR-Set7LSD1nCRB2, p53BP1Transcriptional activation[25, 26]
K20me2/3SUV4-20H1/2LSD1n, DPY-21CRB2, p53BP1, JMJD2Transcriptional silencing, Heterochromatin[25, 27]
K16 acMOFHDACs, Sirt2BRDsTranscriptional activation, DNA repair[28, 29]