Fig. 4
From: MIA-Sig: multiplex chromatin interaction analysis by signal processing and statistical algorithms
Summary of MIA-Sig algorithm. ChIA-Drop putative complexes from ChIA-DropBox pipeline are inputs to the distance test, which assigns p values to each complex to quantify its significance. Refined complexes enable TAD calling directly on the multiplex data. A binomial test identifies frequent contacts among multiple TADs. RNAPII-enriched ChIA-Drop putative complexes are assigned significance according to the level of enrichment