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Fig. 3 | Genome Biology

Fig. 3

From: Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

Fig. 3

The genetic dependence of the formation of short insertions and deletions. a, b The mean number of newly arising short insertions (a) or short deletions (b) generated per sequenced genome in each indicated cell line. Red symbols show the values for individual samples. c A classification of detected short deletion events by sequence context. The minimum length of classified microhomologies was 1 bp. Error bars indicate SEM in ac. d The length of each deletion is shown, color coded according to sequence context. e Cumulative size distribution of genomic deletions in those cell lines in which the total number of deletions in the sequenced clones was greater than 10. f Cumulative size distribution of deletions at two different CRISPR-targeted genomic loci in each of the indicated cell lines, obtained by amplicon sequencing. g Stacked view of all deletions (orange) and insertions (blue) at two CRISPR-targeted loci in four indicated cell lines, shown as the percentage of all sequenced amplicons obtained from genome preparations of cell populations sorted for successful transfection with a plasmid expressing Cas9 and the respective guide RNA

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