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Fig. 2 | Genome Biology

Fig. 2

From: Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

Fig. 2

A base substitution signature of HR deficiency. a De novo NMF of the detected cell line-specific SNV mutation spectra into two components, termed Signature HRD and Signature BG (middle panel), and the error (root-mean-square deviation) of reconstructing the experimental dataset using these two signatures (top panel). The bottom panel shows the individual SNV counts for each sequenced genome, split using NMF into “HRD” and “BG” signatures that are virtually identical to Signature HRD and BG, respectively. b Triplet mutation spectra of Signature HRD and Signature BG shown as the percentage contribution of each triplet mutation type, and COSMIC triplet signature 3 for comparison. c, d Correlation heat map of the experimentally derived triplet signatures to 30 COSMIC signatures using cosine similarity (c) or Spearman’s rank correlation (d)

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