Fig. 3

Aging-related transcriptional profile changes. a The number of genes with evidence of aging-related gene expression (red) and aging-related alternative splicing (blue) changes. b The overlapping rate of DEGs between any two brain regions (the ratio of intersection over union was used to exhibit the overlapping rate). c The overlapping rate of genes with DEUs between any two brain regions. d The overlapping rate of DEUs and genes with DEGs between any two brain regions. e Enriched categories for upregulated (top) and downregulated (bottom) DEGs in aged macaques. f Matrix summary of enrichment in oligodendrocyte, neuron, microglia, endothelial, or astrocyte genes in upregulated and downregulated DEGs of aged macaques