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Fig. 7 | Genome Biology

Fig. 7

From: CRUP: a comprehensive framework to predict condition-specific regulatory units

Fig. 7

Assignment of activity pattern for the comparison of two conditions. For the differential comparison of enhancers in two conditions, C1 and C2, the activity pattern assigned to bin x depends on the empirical p values of bin x and two neighboring bins to both sides (bin x−1, bin x−2, bin x+1, bin x+2). If one of the five empirical p values exceeds the cutoff P, bin x does not represent a differential enhancer between C1 and C2 and is assigned the activity pattern {Tx(C1,C2)=0, Tx(C2,C1)=0}={0,0}. If all five bins show an empirical p value below P and the group mean of C1 is greater than the group mean of C2 (μC1>μC2, bin x represents an active enhancer in C1 and is assigned the activity pattern {Tx(C1,C2)=1, Tx(C2,C1)=0}={1,0}. In the opposite case (μC2>μC1), bin x is active in C2 with an activity pattern of {Tx(C1,C2)=0, Tx(C2,C1)=1}={0,1}

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