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Fig. 6 | Genome Biology

Fig. 6

From: CRUP: a comprehensive framework to predict condition-specific regulatory units

Fig. 6

TAD region containing a differential regulatory unit in the context of rheumatoid arthritis. Enhancer probabilities of two healthy mice (gray) and two Rh. Arth.-like mice (orange). One enhancer in this region (blue rectangle, chr1:128722201–128722800) was found to be only active in the diseased samples. Using RNA-seq experiments performed on the same samples (displayed raw counts are cut at a maximum of 1500), gene expression of the gene Cxcr4 highly correlates with the probabilities of the differential enhancer (orange arrows). The gene is part of the chemokine signaling pathway and also known to play a role in rheumatoid arthritis

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