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Table 3 Comparison of scSplit and demuxlet performance in demultiplexing hashtagged and multiplexed eight individually genotyped PBMC samples (TPR true positive rate, FDR false discovery rate); total cell numbers: 7932; reads per cell: 5835; informative SNVs: 16,058; runtime for matrices building: 35 min, runtime for cell assignment: 20 min

From: Genotype-free demultiplexing of pooled single-cell RNA-seq

Predictions vs Truth

TPR

FDR

Cohen’s Kappa

scSplit

Singlet

0.98

0.13

0.75

 

Doublet

0.35

0.28

 

demuxlet

Singlet

0.79

0.10

0.74

 

Doublet

0.65

0.46