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Table 2 Comparison of scSplit and demuxlet performance in demultiplexing merged three individually genotyped stromal samples (TPR true positive rate, FDR false discovery rate); Total cell numbers: 9567; Reads per cell: 14,495; Informative SNVs: 63,129; Runtime for matrices building: 67 min, Runtime for cell assignment: 55 min

From: Genotype-free demultiplexing of pooled single-cell RNA-seq

Predictions vs Truth

TPR

FDR

Cohen’s Kappa

scSplit

Singlet

0.94

0.02

0.95

 

Doublet

0.65

0.04

 

demuxlet

Singlet

0.93

0.02

0.77

 

Doublet

0.66

0.47