Fig. 5

Transcriptomic correlates of olaparib sensitivity. a Gene Set Enrichment Analysis (GSEA) between olaparib-sensitive and olaparib-resistant PDCs. b Drug response assessment of olaparib and/or saracatinib. c Heatmap representation of SRC pathway encoding gene expressions in olaparib-sensitive and olaparib-resistant PDCs. d A scatter plot demonstrating linear correlation between olaparib AUC and ID2 expression. The correlation coefficient and the P value were obtained using Pearson’s correlation test. e Representative immunohistochemical images of ID2 staining in patient tumor specimens. Scale bars, 50 μm. f The Kaplan-Meier treatment-free survival analysis of patients with high vs. low ID2 protein expression levels. P values in b—two-tailed t test, in d—Pearson’s correlation test, and in f—log-rank test