Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Table 6 Regression analyses relating genera with obesity, birthplace, and age at relocation to the mainland USA. After individually examining the associations of 74 genera with relative abundance > 0.01% with obesity and with birthplace/age at relocation to the mainland USA, the ten genera displayed in this table were found to be overlapping between these two analyses. Regression models for obesity adjusted for age, sex, and center, and regression models for birthplace and age at relocation adjusted for sex and center

	Association with obesity			Association with birthplace and age at relocation to USA			Direction of association
		P value	P value		P value	P value
	Beta	Unadj	FDR adj	Beta	Unadj	FDR adj	Obesity	Early-life exposure to USA	Consistent?
Oscillospira	− 0.139	< 0.001	< 0.001	− 0.071	0.003	0.0111	Negative	Positive	No
Unclassified.Clostridiales	− 0.207	< 0.001	< 0.001	0.101	< 0.001	< 0.001	Negative	Negative	Yes
Unclassified.Ruminococcaceae	− 0.138	< 0.001	< 0.001	0.067	0.005	0.016818	Negative	Negative	Yes
Unclassified.Christensenellaceae	− 0.426	< 0.001	< 0.001	0.158	0.003	0.0111	Negative	Negative	Yes
Unclassified.Coriobacteriaceae	− 0.235	< 0.001	< 0.001	0.137	0.001	0.0056923	Negative	Negative	Yes
Megasphaera	0.277	< 0.001	< 0.001	− 0.167	0.003	0.0111	Positive	Positive	Yes
Acidaminococcus	0.318	< 0.001	< 0.001	− 0.3	< 0.001	< 0.001	Positive	Positive	Yes
Anaerotruncus	− 0.18	< 0.001	< 0.001	− 0.083	0.011	0.03256	Negative	Positive	No
Unclassified.Victivallaceae	− 0.144	0.009	0.037	0.118	0.004	0.014095	Negative	Negative	Yes
Unclassified.YS2	− 0.217	0.004	0.0185	0.205	< 0.001	< 0.001	Negative	Negative	Yes

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