Fig. 1
From: Quantitative MNase-seq accurately maps nucleosome occupancy levels
Kinetics of nucleosome release from chromatin. Each position x along the genome is characterized by a nucleosome occupancy (i.e., the fraction of cells in which position x is occupied by a nucleosome), a rate of nucleosome release (rate constant k1(x)), and a rate of nucleosome decay (over-digestion, rate constant k2(x)). Digesting a population of C cells with a concentration [E] of MNase, for a time t, will result in a number N(x, [E], t) of free mononucleosomes from each position x (Additional file 1). Nucleosomes from the more accessible regions of chromatin (x) may be released faster than nucleosomes from the regions of less accessible chromatin (y)