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Table 1 Computational time for analyzing differently sized data sets, for count-based mQTL mapping methods. Computing time is based on analysis of 100,000 SNP-CpG pairs with baseline simulation parameters and varying sample size, using a single thread on a Xeon E5-2683 2.00-GHz processor

From: IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis

Method

Sample size

Time (min)

IMAGE

50

295.87

100

410.10

150

543.48

IMAGE-I

50

81.10

100

63.93

150

108.27

IMAGE-A

50

16.63

100

36.51

150

69.25

MACAU

50

214.85

100

476.58

150

883.60

BB

50

417.63

100

2029.44

150

3967.03