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Fig. 2 | Genome Biology

Fig. 2

From: IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis

Fig. 2

IMAGE achieves higher power to detect mQTL across various simulation settings. Power is measured by number of true mQTL detected at a false discovery rate (FDR) of 0.05. Each simulation setting is based on 10 simulation replicates, each including 10,000 simulated SNP-CpG pairs, 10% of which represent true mQTL. a We vary h2, the background heritability, to be either 0, 0.3, or 0.6, while maintaining other parameters at baseline. b We vary ρ, the proportion of common environmental variance, to be either 0, 0.3, or 0.9, while maintaining other parameters at baseline. The middle panel in a and the left panel in b correspond to the baseline simulation setting. Increasing both h2 and ρ, which capture genetic and common environmental background effects, respectively, results in increased power for methods that use ASM information (IMAGE and IMAGE-A), but losses in power for methods that do not use ASM information (IMAGE-I, MACAU, GEMMA, BB). FDR false discovery rate

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