Table 2 Literature survey of age acceleration
From: Systematic underestimation of the epigenetic clock and age acceleration in older subjects
Reference | Phenotype | AIM | SIG | Age acceleration method | ||
|---|---|---|---|---|---|---|
Horvath [14] | Obesity | No | Yes | Residuals of DNAm age regressed on chronological age | ||
Marioni et al. [15] | All-cause mortality | Yes | Yes | Δ-age | ||
Levine et al. [16] | Lung cancer incidence | Yes | Yes | IEAA | ||
Levine et al. [17] | Neuritic plaque | Yes | Yes | Residuals of DNAm age regressed on chronological age and sex | ||
Horvath et al. [18] | Parkinson’s disease | Yes | No | AgeAccel | ||
Yes | No | IEAA | ||||
Yes | Yes | EEAA | ||||
Horvath et al. [19] | Down syndrome | No | Yes | Residuals DNAm age regressed on chronological age in controls | ||
Marioni et al. [20] | Fitness variables | Yes | Yes | Residuals DNAm age regressed on chronological age | ||
Horvath et al. [21] | HIV | No | Yes | AgeAccel | ||
Horvath et al. [22] | Alzheimer in the cerebellum | Yes | No | Residual DNAm age against chronological age in non-cerebellar brain sample | ||
Horvath et al. [23] | Longevity | No | Yes | AgeAccel | ||
No | Yes | IEAA | ||||
No | Yes | EEAA | ||||
Walker [24] | Multifocal developmental disorders | No | No | Residuals DNAm age regressed on chronological age | ||
Lin et al. [25] | Life expectancy | Yes | Yes | Δ-age | ||
Perna [26] | All-cause mortality | Yes | Yes | Δ-age | ||
Cancer mortality | Yes | Yes | Δ-age | |||
Cardiovascular mortality | Yes | Yes | Δ-age | |||
Horvath [27] | Huntington’s disease | No | Yes | Residuals DNAm age regressed on chronological age | ||
Levine et al. [28] | Age at menopause | Yes | Yes | AgeAccel | ||
Horvath [29] | Race/ethnicity | Yes | Yes | EEAA | ||
Chen et al. [30] | Time of death | Yes | Yes | EEAA | ||
Yes | Yes | IEAA | ||||
Yes | Yes | AgeAccel | ||||
Simpkin et al. [31] | Birth weight | No | Yes | Δ-age | ||
Gao et al. [32] | Smoking status | Yes | No | Residuals DNAm age regressed on chronological age | ||
Cumulative exposure | Yes | No | Residuals DNAm age regressed on chronological age | |||
Cessation time | Yes | No | Residuals DNAm age regressed on chronological age | |||
Breitling et al. [33] | Frailty | Yes | Yes | Δ-age | ||
Ward-Caviness et al. [34] | Air pollution | No | Yes | Residuals DNAm age regressed on chronological age | ||
Yes | Yes | EEAA | ||||
Yes | Yes | IEAA | ||||
Levine et al. [35] | HIV-associated neurocognitive disorders | Yes | Yes | Residuals DNAm age regressed on chronological age | ||
Armstrong et al. [36] | Longevity | No | Yes | AgeAccel - Hannum | ||
McKinney et al. [37] | Schizophrenia duration | No | No | Residuals DNAm age regressed on chronological age | ||
Wolf et al. [38] | PTSD hyperarousal | No | Yes | Residuals DNAm age regressed on chronological age | ||
PTSD severity | No | No | Residuals DNAm age regressed on chronological age | |||
Quach et al. [39] | Diet and lifestyle | Yes | Yes | EEAA | ||
Diet and lifestyle | Yes | Yes | IEAA | |||
Binder et al. [40] | Time to menarche | No | Yes | AgeAccel | ||
Pubertal tempo | No | Yes | AgeAccel | |||
Breast fibro-glandular volume | No | Yes | AgeAccel | |||
Dugué [41] | Mortality | Yes | Yes | Residuals DNAm age regressed on chronological age | ||
Yes | Yes | IEAA | ||||