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Table 1 Regression analysis of epigenetic age acceleration of four brain tissues and blood from the London Brain Bank cohort [9] versus brain Braak stage and of two brain tissues from the Mount Sinai cohort [12] versus amyloid plaque levels

From: Systematic underestimation of the epigenetic clock and age acceleration in older subjects

 

London cohort

London cohort (age in model)

Mount Sinai cohort (age in model)

 

Coefficient

P value

Coefficient

P value

Coefficient

P value

Prefrontal cortex

0.434

0.164

− 0.345

0.107

− 0.029

0.629

Entorhinal cortex

0.969

0.004

0.424

0.125

Sup. Temporal Gyrus

0.653

0.019

− 0.062

0.786

0.004

0.944

Cerebellum

1.127

0.002

− 0.059

0.788

Blood

− 0.278

0.632

− 0.090

0.870

  1. Shown for each cohort the coefficient and P value for the regression analysis between age acceleration and Braak stages (London cohort) or amyloid plaque levels (Mount Sinai cohort) with chronological age as a covariate