Fig. 3
The first enhancer in an EC maintains crucial functions in gene regulation. a The number of Hi-C-connected promoters and enhancers for different chain enhancers. b The betweenness centrality (BC) scores for different enhancers. c The fold enrichment of the top 30 TFBSs specific to promoters regulated by ECs in GM12878 and K562 cell lines (profiled across promoters (P), E1, E2, and E3+ enhancers). d The fraction of EC enhancers that either maintain or switch their position in an EC across four tissues. N1, N2, and N3 are the total number of enhancers for each category of enhancers combined across four tissues. e The density of expression quantitative trait loci (eQTL) variants for different EC enhancers. “Whole blood” eQTLs were selected for GM12878 and K562 enhancer chains, “breast mammary” eQTLs for HMEC, and “artery aorta” eQTLs for HUVEC. *p < 0.05, **p < 0.001, ***p < 1 × 10−10; p values are calculated using the Wilcoxon rank-sum test and the binomial test